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AI-ready · Judgment

You pull a structure prediction with high overall confidence but a low-confidence loop right at the binding interface you care about. How do you decide whether that region is trustworthy enough to guide mutagenesis design?

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Overall confidence scores are close to useless for my purposes if the region I actually care about scores low, so I look at per-residue confidence, not the summary number, before I do anything else.…

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