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Communication & influence · Persuasion under skepticism

You're at a pre-IND meeting and an FDA reviewer signals the agency won't accept your surrogate endpoint. You have the room's attention for the next few minutes. How do you make the case without appearing to argue past their concern?

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I'd open by naming their concern in their language, because reviewers disengage the moment they feel unheard: the surrogate has to predict clinical benefit, not just correlate.

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