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Interviewers ask this kind of question to surface how you think, not what you remember. The strongest answers are specific, calmly told, and end on what changed.

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Judgment & ambiguity · Calibrating confidence

After a scale-up change to your manufacturing process, the comparability data mostly overlays the old process, but one glycosylation attribute sits at the edge of the historical range. Leadership asks: are the new batches equivalent? How confident are you, and how do you answer?

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I'd answer with a calibrated 'mostly, with one open question' rather than a clean yes.

The full answer: structure, worked example, likely follow-up.

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