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Judgment & ambiguity · Prioritizing without clear signal

Three programs each hit a snag the same week: an assay drifting out of qualification, a CMC scale-up giving inconsistent yield, and a tox finding that might be a formulation artifact. You can only give one your full attention today. How do you sequence them?

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I sequence by irreversibility and by what could hurt a patient, not by which team is loudest.

The full answer: structure, worked example, likely follow-up.

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